Less risk of lethal prostate cancer in coffee drinker

J Natl Cancer Inst. 2011 May 17. Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study. (Harvard School of Public Health, Boston, MA)

• Prospective analysis of 47,911 men (Health Professionals Follow-up Study)
• Coffee >6 cups/day compared to no coffee
• Slightly lower risk for overall prostate cancer (425 vs 519/100k person-year)
• Substantially lower risk for lethal prostate cancer (34 vs 79/100k person-year)
• No difference with non-advanced/low-grade prostate cancer
• Regardless of decaf or caffeinated
• Possible links: insulin, testosterone, anti-oxidant, anti-inflammatory

Coffee reduces ER(-) breast cancer risk

Breast Cancer Res. 2011 May 14. Coffee consumption modifies risk of estrogen-receptor negative breast cancer. (Karolinska Institutet, Stockholm, Sweden)

• Swedish, population-based case-control study
• 2,818 cases and 3,111 controls
• post-menopausal women aged 50 - 74 years
• Coffee >5 cups/day compared to <1 cup/day
• Modest decrease in overall breast cancer risk
• Significant decrease in estrogen receptor-negative breast cancer risk